In recent years, Arginine has been one of the most studied amino acids. Initially it garnered interest from the performance nutrition industry for its stimulating effects on the body's natural production of growth hormone. Then it became popular as an aid to metabolic nitric oxide synthesis. There is a growing body of scientific literature that indicates L-Arginine supplementation may help improve physical performance and decrease fatigue because of the vasodilating effects of increased nitric oxide production. More recent studies have indicated that Arginine may be able to enhance lean muscle mass and help reduce body fat.

In one study, researchers sought to assess the effects of Arginine supplementation on body composition and strength. Twenty soccer players in two groups were subjected to eight weeks of thrice-weekly weight training. One group received three grams of L-Arginine along with one gram of vitamin C daily, while the control group received only one gram of vitamin C. The Arginine group showed a significant increase in body-weight (66.4 ± 6.1; 67.84 ± 6.8 kg), lean body mass (60.38 ± 6.05; 62.07± 5.9 kg), leg muscle strength, and a decrease in both body fat (6.02 ± 0.6 - 5.77 ± 0.59 Kg) and body fat percent (9.45 ± 0.8 to 8.66 ± 0.77) (p<0.05). By comparison, the control group (ie: non-Arginine group) registered no significant change in body composition. Researchers concluded that daily oral supplementation of L- Arginine for eight weeks positively altered measurements of strength and fat-free mass, suggesting that the strategy of targeted nutrition had the ability to improve the muscular responses to weight training programs.


In another study, thirty-three type 2 diabetic patients participated in a hypocaloric diet coupled with an exercise training program for twenty-one days. They were divided into two groups. The first group received 8.3 grams of L-arginine daily, while the second group received a placebo. Although group body weight, waist circumference, daily glucose profiles, fructosamine, insulin, and homeostasis model assessment index significantly decreased for both groups as a result of the exercise, the group receiving the L-arginine showed a significantly greater reduction in FM and waist circumference, while preserving FFM. A third study tested the effect of L-arginine supplementation in diet-induced obesity in male rats. For fifteen weeks, starting when the rats were four weeks old, one group received a high-fat (HF - 40% energy) diet, while the second group received a low-fat (LF - 10% energy) diet . The results of the diet were predictable. The HF group had 18% higher body weight gains and 74% higher weight of major white fat deposits compared to the LF group.

Then, starting at nineteen weeks of age, rats in each dietary group were supplemented for twelve weeks with either 1.51% solution L-arginine-HCl, or 2.55% solution L-alanine (control group) n drinking water. Arginine group members were individually pair-fed with Alanine control group members to ensure energy intake for both groups was similar. Over the additional twelve weeks of the study, white fat deposits in the control rats increased by 98%, while the Arginine fed rats increased by only 35%. The arginine treatment reduced the relative weights of white fat deposits by 30% and enhanced the weight of the soleus muscle by 13%, the extensor digitorum longus muscle by 11%, and brown fat deposits by 34%, compared with control rats.

In addition, Arginine supplementation resulted in lower serum concentrations of leptin, glucose, triglycerides, urea, glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance. Researchers concluded that Arginine supplementation appears to have a nutrient partitioning effect that enhances lean muscle rather than fat gain in a high calorie diet. They further stated that Arginine supplementation appears to be useful for improving body composition profile and reducing white fat deposits in diet-induced obese rats.

These studies suggest that L-Arginine is a must-have for any athlete serious about improving performance and optimizing body composition.

Unfortunately, most oral L-Arginine supplements have very poor absorption rates because of enzyme called arginases that break it down in the digestive tract. Gaspari Nutrition's Research and Development Department was able to solve this problem in its ultra-advanced pre-workout product GASPARI NUTRITION SUPERPUMP 3.0 .

GASPARI NUTRITION SUPERPUMP 3.0  contains a revolutionary form of clinically studied patented arginine called inositol arginine silicate (aka Nitrosigine). By attaching inositol and silicon to the Arginine molecule, the Arginine is able to avoid a high degree of degradation and help increase blood vessel relaxation five times more than plain Arginine hcl.

If you are looking for a formula that combats the poor absorption rates of regular Arginine, and ensures more Arginine gets to where it does the most good, then GASPARI NUTRITION SUPERPUMP 3.0  is the perfect choice!


  • Wenjuan Jobgen, Cynthia J. Meininger, Scott C. Jobgen, Peng Li, Mi-Jeong Lee, Stephen B. Smith, Thomas E. Spencer, Susan K. Fried and Guoyao Wu: Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats. Journal of Nutrition, Vol. 139, No. 2, 230-237, February 2009
  • Gerseli et al.: The effects of oral L-arginine supplementation on muscular strength in young soccer players, Journal of Sports Science and Medicine, Supp. 10:35, 2007.
  • Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rbaiotti G, Gatti R, Piatti P: Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrin Metab. 2006 Nov; 291(5): E906-12
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